Use of cannabidiol in child with refractory seizures: sustained clinical improvements

Case presentation: A 7 month-old was admitted for presenting a clinical condition suggestive of an Inborn Error metabolism, as she showed development delay, early onset refractory seizures and generalized dystonia associated with infectious events. After 3 years, remained unresponsive to treatment, over 15 tonic-clonic events per day, complementary exams were nonspecific, EEG left temporo-occipital intermittent slow activity MRI revealed hypersignal on T2, diffusion restriction in the medial longitudinal fascicles. Also, genetic testing inconclusive, though it indicated mitochondriopathy. Due this suspicion, Valproate suspended Cannabidiol (400 mg/day) recommended seizure control, along Phenobarbital (5 mg/kg/day), Oxcarbazepine (35 Clobazam (1 mg/kg/day) co-factors (L-carnitine, thiamine riboflavin). Since therapy established, presented full control increased her process. Therefore, is understood that relevance case closely linked need adequate appropriate prescription.